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Madecassic acid

CAS No. 18449-41-7

Madecassic acid( —— )

Catalog No. M18146 CAS No. 18449-41-7

Madecassic acid is extracted from the whole herb of Centella asiatica.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Madecassic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Madecassic acid is extracted from the whole herb of Centella asiatica.
  • Description
    Madecassic acid is extracted from the whole herb of Centella asiatica.
  • In Vitro
    Western Blot Analysis Cell Line:RAW 264.7 murine macrophage cell Concentration:50, 100, 150 μM Incubation Time:24 h followed by LPS (1 μg/mL) treatment for 4 h Result:Inhibited LPS-induced iNOS and COX-2 protein expression i in a dose -dependent manner.
  • In Vivo
    Animal Model:Colitis mice induced by2.5% DSS Dosage:25?mg/kg/day Administration:Oral gavage (p.o.) , 10 days Result:Decreased the number of γδT17 cells in the colons.Reduced the expression of IL-17 in colon tissues.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    18449-41-7
  • Formula Weight
    504.71
  • Molecular Formula
    C30H48O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (123.84 mM)
  • SMILES
    C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(C[C@H]([C@@H]3[C@@]4(C[C@H]([C@@H]([C@@]3(C)CO)O)O)C)O)C)[C@@H]2[C@H]1C)C)C(=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang H, et al. J BUON. 2014 Apr-Jun;19(2):372-6.
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